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العنوان
Urinary Nitric Oxide in Children and Neonates with Acute Lung Injury /
المؤلف
Kamer El-Dawla, Haitham Mohamed.
هيئة الاعداد
باحث / Haitham Mohamed Kamer El-Dawla
مشرف / Ibrahim Mohamed Mar’i
مشرف / Abd El-Hakim Abd El-Mohsen Abd El-Hakim
مشرف / Manal Mohamed Saber
الموضوع
Newborn infants - Diseases.
تاريخ النشر
2009.
عدد الصفحات
125 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2009
مكان الإجازة
جامعة المنيا - كلية الطب - Pediatrics
الفهرس
Only 14 pages are availabe for public view

from 137

from 137

Abstract

Summary and conclusion:
Acute lung injury (All) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema and inflammation. The development of ALI/ARDS is associated with several clinical disorders including direct pulmonary injury from
pneumonia and aspiration as well as indirect pulmonary injury from trauma, sepsis, and other disorders such as acute pancreatitis and drug overdose (Leaver and Evans, 2007).
Respiratory distress syndrome of the newborn marked by dyspnea with cyanosis, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause (CRISP Thesaurus, 2006),
Nitric oxide or Nitrogen monoxide IS a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air
Summary and Conclusions pollutant produced by automobile engines and power plants
(Galloway et aI., 2004).
Nitric oxide is now thought to play a role in blood pressure regulation, control of blood clotting, immune defense, digestion, the senses of sight and smell, and possibly learning and memory. Nitric oxide may also participate in disease processes such as diabetes, stroke, hypertension, impotence, septic shock, and longgterm depression (Janeway, 2005).
This study investigated the rule of Nitric Oxide as a valuable guide for diagnosis of acute lung injury, and as an index of progression of the disease and its correlation with the prognosis.
The urinary nitric oxide level was evaluated in the newly diagnosed acute lung injury (All) patients at the first day then at the fourth day of the diagnosis. Urinary nitric oxide level was conducted on 2 groups of subject: group I (45 neonates) and group TI (45 children), each group consist of 30 patients & 15 control subject. The patients were selected from the inpatient department and neonatal care unit of Suzan Mubarak University Hospital of Pediatrics, their age’s ranged from 1 day to 12 years and were diagnosed as pneumonia or respiratory distress syndrome within 2 days. They were normotensive, nonsmoker,