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Abstract Schistosomiasis is a highly prevalent parasitic infection worldwide and it is estimated that more than 200 million people are currently infected and more than 779 million people are at high risk of infection, 85% of those live in Africa. Schistosomiasis is endemic in 76 countries, with 46 of those countries located in Africa. In the last five years, schistosomiasis became one of the neglected tropical diseases The aim of this study was to investigate the last record of ministry of health that schistosomiasis both mansoni and hematobium were decreased to less than 1% of population and to see if schistosomiasis should be considered one of the neglected tropical diseases or it should be put in our mind and give it more efforts for control and eradication. This study was conducted on 80 patients attending for colonoscopic examination due to different complaints. We performed for every case colonoscopy, rectal snip and its examination by transparency technique and pathology, Kato Katz technique, nucleopore filtration technique and abdominal ultrasonography together with history taking and clinical examination. We concluded that Schistosomiasis should not be considered one of the neglected tropical diseases in our country, transparency technique was the gold standard method for diagnosing schistosomal infection both mansoni and hematobium and the percentage of schistosomiasis by this technique was 21.25% followed by pathology of rectal snip followed by parasitological methods Kato Katz technique and nucleopore filtration technique, the most accurate site for rectal snip is rectal valves, and Schistosomiasis can be a cause of chronic abdominal pain. Key words: · Schistosomiasis. · Rectal snip. · Colonoscopy |