الفهرس 
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Abstract
During the study period, 60 patients (children and adolescents) with type I diabetes mellitus, were enrolled, with mean age = 9.48 year ±3.7.
20 apparently healthy individuals, were served as control group, mean age= 5.4year ±3.4.
The patient group was classified into 2 subgroups.
Group I: include 30 patients with type 1 diabetes mellitus with disease duration> 3 years (we called them, old diabetics), with 13 male and 17 females, mean age = 11.3 year ±3.
Group II: include 30 patients with type 1 diabetes mellitus with disease duration <3 years (we called them new diabetics), with 14 males and 16 females, mean age = 7.6 year ±3.4.
All the patients were subjected to the following investigations
1. Routine investigations
Fasting blood sugar (FBS), renal function testes (RFT): serum urea and serum creatinine, glycated hemoglobin (HbAlc), and microalbuminuria.
2. Fundus exa_mination and Peroneal motor nerve conduction velocity (PMNCV).
3. Specific investigations
Measurement of serum level of Matrix Metalloproteinases-2 (MMP-2) .
Results of different groups were compared with each other and we can summarized as follow:
1- Serum level of MMP-2 was higher in diabetic patients versus control group and the difference was statistically significant (PPvalue <0.0001).
2- Serum level of MMP-2 was higher in diabetic patients with microangiopathic abnormalities versus diabetic patients without microangiopathic abnormalities and control groups and the difference was statistically significant (P-value <0.005).
3- There was significant positive correlation between serum level of MMP-2 and disease duration of type 1 diabetes mellitus, fasting blood sugar and microalbuminuria .
In summery, our study observed that serum level of MMP-2 is increased in diabetic patients compared to healthy subjects and also serum level of MMP-2 is increased in diabetic patients with microangiopathic abnormalities compared to diabetic patients without microangiopathic abnormalities, and this may reflect abnormal ECM metabolism.