الفهرس 
Bronchial asthmaOnly 14 pages are availabe for public view
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Abstract
Many studies have shown the implications of CD14 in the
pathogenesis of asthma & atopy by modulating the effect that innate
responses to bacterial pathogens have on adaptive immunity. The role of
single nucleotide polymorphisms (SNPs) of CD14 in asthma remains
inconclusive and discrepancy was found between different populations.
We assessed CD14 profile in a group of Egyptian asthmatic infants
and young children through measurement of its plasma level and
screening for CD14 promoter polymorphism with special emphasis on the
relation of measured parameters to different clinical (age of onset,
severity, duration) and laboratory data (IgE-peripheral blood esinophil
count) and allergic skin prick tests. Forty four asthmatic Children aged
6m to 5yr (30.6 ± 15.9 month) and matched control group of 40 children
were recruited for the present study.
Results revealed that the plasma level of CD14 was higher in cases
(mean level = 1867 ± 563.3 ng/ml) than controls (mean level = 1312.9 ±
611.8 ng/ml) (P < 0.0001). Genotype analysis of patients and controls,
showed an observed but statistically in significant difference in the
expression of the homozygous CC genotype which was higher in
asthmatics (22.7%) and TT genotype which was higher in controls
(22.7%). In conclusion, CD14 gene polymorphism may contribute to
inherited predisposition to asthma in Egyptian children.
Key words: Asthma – CD14 – polymorphism