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Abstract The maser thesis include four main chapter I- Aim of the work The work aimed to prepare and characterize a new guanidinium ligand and its metal complexes aiming to study their effects on both microbial and tumour diseases II- Introduction This chapter includes an overview of the previous researches on complexes of guanidine ligands and their applications III- Experimental This chapter contains the chemical reagents and equepiments used for measurement of different parameters all over the work as follow: 1) Preparation of the guanidine ligand and its metal complexes. 2) Characterization of the ligand and its complexes using different methods: • Physical techniques such as molar conductance and magnetic susceptibility • Elemental analyses (C, H, N, Cl and M). English Summary - 145 - • Spectral techniques as IR, (UV- Vis.), 1HNMR, mass spectra and ESR measurements. • Thermal techniques as DTA. and TGA 3) Measurement of biological activity for the prepared complexes. iv. Results and discussion This chapter includes Characterization of the ligand and its complexes. The ligand N- (amino [2- hydroxy] methylene) amino - methylene – carbono hydrazonic diamide was prepared as follow: 1- Condensation of thiourea with hydrazine hydrate (1:1) for three hours to obtain the hydrazide. 2- Condensation of salicylaldehyde with the hydrazide (1:1) for three hours to give the ligand. Metal complexes of N- (amino [2- hydroxy] methylene) amino - methylene – carbono hydrazonic diamide ligand have been synthesized and characterized by elemental analyses, IR, UV- VIS spectra, Magnetic moments, Conductances, Thermal analyses (DTA- TGA) and ESR measurements. The IR data show that, the ligand behaves as neutral bidentate or mono basic bidentate. Molar conductances in DMF indicate that, the complexes are non- electrolytes. The ESR spectra of solid Cu(II) complexes show axial type symmetry with g// > g┴ > 2.00, indicating a d(x 2 -y 2 ) ground state with significant covalent bond character, The spectrum of Cu(II) complex (2) [(L)2(Cu)2(OAc)2].3H2O is a characteristic of the triplet state of a dimer species and the distance found between the two Cu(II) centers is 4.2 A°. Complexes showed English Summary - 146 - chemotherapeutic effects where they showed inhibitory effect on the hepatocellular carcinoma (HepG- 2 cell line) in comparison with the known standard drug. |