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Abstract Hepatocellular carcinoma is the commonest primary liver malignancy. Eighty percent of HCCS arise in patient with liver cirrhosis especially due to hepatitis B infection the commonest cause of HCC world wide, hepatitis C infection in which the lead-time from infection to HCC may be 25 years or more, alcoholic liver cirrhosis and haemochromatosis. The pathogenesis of HCC when associated with liver cirrhosis is related to chronic inflammatory process within the liver. The clinical presentation varies depending on the liver disease, in the presence of liver disease, malignant change, in the liver may be marked by rapid deterioration and decompensation with encephalopathy and asictes. Special investigations for HCC include abdominal ultrasound, helical CT scan and MRI. Preoperative evaluation of the functional hepatic reserve is done to decrease the risk of postoperative liver failure. Comparison between cases of primary hepatocellular carcinoma in upper & lower Egypt from first of January 2011 to last of December 2011, we select cases of primary hepatocellular carcinoma in upper Egypt from clinic of Aswan oncology society and in lower Egypt from clinic of the Summary & Conclusion - 167 - National Liver Institute of Menofia University where cases of primary hepatocellular carcinoma are coming for follow-up. |