الفهرس 
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Abstract
Nonalcoholic fatty liver disease (NAFLD) is emerging as one or the
most common liver disorders worldwide. Excessive accumulation of
triglycerides (TG) in hepatocytcs is the hallmark of l\AILD. The
metabolic pathways leading to the development of hepatic steatosis are
multiple. including increased de novo fat synthesis (I ipogenesis).
Targeting the lipogenic pathway may help to prevent hepatic sleatll,>is.
Researchers found that met form in. a drug widely used to treat I ype I I
diabetes. inhibits fatty acid synthesis so it may help to prevent the earl;
onset of liver damage and NAFLD progression. Therefore. the present
study was undertaken to examine the effect of mctforrnin on fattv liver
induced by orotic acid (OA) in experimental rats.