الفهرس 
Neurological complications after cardiac surgeryOnly 14 pages are availabe for public view
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Abstract
Neurological complications after cardiac surgery remains one of the most serious complications either in adult or pediatric cardiac surgery . The most difficult point is the early diagnosis of these complications .Using of biochemical markers may be a good diagnostic methods if proved to has a good sensitivity and specificity in early diagnosis . There are several markers , the most important one is the Sl00B protein .
In our study , we measured the levels of S100B protein in 40 infants aged 12 months or less with congenital heart disease who underwent cardiac surgery . Patients was classified into open and closed groups , each group included 20 patients . Patients in open group underwent total correction of ASD , VSD ,and partial atrioventricular canal defect with CPB and moderate hypothermia . Closed group included 20 patients underwent closed cardiac surgery for closure of PDA , pulmonary artery banding or Rt MBT shunting without CPB .
Samples for S100B protein were taken before surgery , at the end of CPB in open group [ and at the end of surgery in closed group ] and 24 hours postoperative .There was no significant difference between both groups regarding the age of the patients . Regarding the peroperative S100B protein , there was no significant difference between both group . At the end of CPB [ and at the end of surgery in closed group ] there was high significant difference between both group [ much higher in open group ] 24 hours postoperative , there was no significant difference between both group .
There was negative correlation between S100B and age and body weight in both group . There was positive correlation between S100B and cross clamp time , CPB time , ventilation time , inotropic support time , ICU stay , hospital stay time and surgical time . There was convulsion in 2 cases of open group which responded to medical treatment and these two cases recovered normally without any neurological complications . In these two patients preoperative S100B and at the end of CPB were the same as other non complicated patients , but 24 hours postoperative S100B was elevated much higher in these complicated patients and decreased after 48 hours .