الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
In the present investigation, the 2-pyridinone derivative was
synthesized by treatment of acetyl acetone with cyanoacetamide in presence
of base. 4,6-Dimethyl-2-oxo-1,2-dihyDROPyridine-3-carbonitrile (22) was
alkylated, after its treatment with 60% sodium hydride in anhydrous N,Ndimethylformamide,
with 2-chloroacetonitril to give two alkylated
derivatives, O- and N-alkyl 139 and 140 respectively. The O- and N-alkylated
derivative were separated by column chromatography with ethyl acetate :
chloroform (1:10) as eluent to give 139 and 140 in 49 %, 34% respectively.
The derivative 139 was cyclized, by its treatment with sodium ethoxide in
absolute ethanol to afford the furopyridine derivative 141. The N-alkylated
140 was allowed to react with phenylisothiocyanat in presence of divided
sulfur, according to the reported method,25 to give the N-pyridothiazol 142.
On the other hand, when 22 was reacted with acrylonitril in presence of
triethylamine afforded 1-(2-cyanoethyl)-4,6-dimethyl-2-oxo-1,2-
dihyDROPyridine-3-carbonitrile (143) in good yield 95 %. Also, to synthesized
1-[(4-amino-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazol-5-yl)methyl]-4,6-
dimethyl-2-oxo-1,2-dihyDROPyridine-3-carbonitrile (144) by reaction of 143
with PhNCS/S under the same condition used for synthesized derivative 142.
(scheme 1).
Part.