الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Ovariectomy increases the risk of cardiovascular disease and accelerates osteoporosis. Osteoporosis characterized by osteopenia and degeneration of bone microstructure, leading to increasing bone brittleness and tendency for bone fracture. A dramatic deficiency of female sex hormones is the most important factor to ovariectomized (OVX) and postmenopausal women osteoporosis. So hormonal replacement therapy (HRT) should theoretically be the best choice for the prevention and treatment of postmenopausal osteoporosis, unfortunately, due to the many side effects of HRT as well as cultural differences; acceptance of HRT is extremely low in women. Non-hormonal therapy or alternative therapy may be more acceptable in women for the treatment and prevention of osteoporosis.
The present data are summarized as follows:
First: When normal rats were fed on diet supplemented with (15% SbO or 10% SO) daily for 2 months, the results illustrated that phytoestrogens were safe, regarding their positive effect on the most tested parameters.
Second: When rats subjected to bilateral surgical ovaryectomyzed the present data recorded several alterations associated with hormonal deficiency in OVX rats including.
Third: Feeding OVX rats on standard diet supplemented with either 15% SbO or 10% SO has shown decreased bone resorption. This effect was observed mainly in terms of modulating BMD and minerals (Ca, P and Mg).
So it can conclude that diets rich in phytoestrogens including SbO and SO are useful and nearly have the same effect in improving bone alterations associated with OVX, through different mechanisms including hypolipidemic effects, decreased oxidative stress and inflammatory reaction, indicating their protective role against bone loss related to bilateral ovariectomy.