الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Cancer is considering one of the most common disease at this time. It is considering a big danger which threatens a lot of societies, which lead to death in a lot of individuals especially in developed countries.. According to a recent report by the World Health Organization (WHO) now more than 10 million cases of cancer per year worldwide. In 2003, it is estimated that approximately 1,300,000 new cases of cancer will be diagnosed, and more than 550,000 people will die from cancer in the United States alone. Many studies reported that the Western dietary pattern with its higher intake of red and processed meats, sweets and desserts and fried foods has been associated with higher risk of colon, breast, prostate and several other cancers. On the other hand, a prudent dietary pattern with its higher intake of fruits, vegetables, whole grains and cereals contributing to increased levels of antioxidants, essential minerals such as selenium, dietary fibers etc has been associated with a marked lower risk of many cancers. Also, strong epidemiological evidence suggests that regular consumption of fruits and vegetables can reduce cancer risk. For example, it is reviewed 200 epidemiological studies that examined the relationship between intake of fruits and vegetables and cancer of the lung, colon, breast, cervix, esophagus, oral cavity, stomach, bladder, pancreas, and ovary. Recently, the use of dietary chemoprevention strategies has gained significant interest. Research investigating the use of diet-derived chemoprevention compounds i.e. phytochemicals may have significant impact on qualifying or changing recommendations for high-risk cancer patients and thereby increase their survival through simple dietary choices with easily accessible foods. Phytochemicals are bioactive non-nutrient chemical compounds found in plant foods such as fruits, vegetables, grains, and other plant foods. Amongst phytochemicals, phenolics are compounds possessing one or more aromatic rings with one or more hydroxyl groups and generally are categorized as flavonoids (including flavonols, flavones, catechins, flavanones, anthocyanidins, and isoflavones), phenolic acids, stilbenes, coumarins, and tannins. Many phytochemicals are potent effectors of biologic processes and have the capacity to influence disease risk via several complementary and overlapping mechanisms. Sweet cherries (Prunus avium L.) are important commercially as a table fruit. Consumption of sweet cherry has been associated with beneficial health effects, for instance it is reported that the consumption of sweet cherries alleviates arthritis and gout-related pain. Reduction of the proliferation of human colon cancer cells has been specifically associated with the consumption of cherries. Cherries are considered a natural source of antioxidants, including anthocyanins and polyphenols compounds that can reduce the risk of degenerative diseases caused by oxidative stress, such as cancer, cardiovascular disease and stroke. Pumpkin (Cucurbita moschata) is widely grown and consumed as dietary constituent and agricultural product among peasants in Egypt. It is rich in polysaccharides, carotene, mineral salts, vitamins, and other substances beneficial to health, resulting in various processed food products being developed. Pumpkin has received considerable attention in recent years because of the nutritional and health protective value of the seeds as well as the polysaccharides from the fruits. Several preliminary studies (in vitro as well as in vivo) with crude pumpkin extract and its various purified fraction– including proteins and polysaccharide–have shown anticancer activity against melanmoa, ehrlich ascites and leukaemia. However, traditional use, pharmacology of sweet charry and pumpkin has not yet been explored scientifically. As such, the present study was carried out to prepare aqueous, ethanol and methanol extracts
from Sweet cherries (Prunus avium L.) and Pumpkin (Cucurbita moschata) fruits pulp, rich in phenolic compound. Also, evaluate the anticancer activity of the different extracts of these plant fruits against in vitro Ehrlich Ascites Carcinoma (EAC) tumor model will be in the scope of this study. The obtained data could be summarized as follow : The Effect of extraction methods on the antioxidant activity and total phenolics of tested plants 1. Data of the antioxidant activities and total phenolics of three sweet cherry extracts showed decrease in absorbance of β-carotene in the presence of different cherry extracts (and well-known antioxidants used as standards) with the oxidation of β-carotene and linoleic acid. Sweet cherry extracts showed considerable differences in antioxidant activity (AA = 61.44-84.13%) when it was calculated by the four different methods used in this study. Methanolic extract (MeOH)
showed strong activity probably due to its high phenolic content(162.34 mg gallic acid 100 g-1 fresh weight). Aqueous extract showed relatively low antioxidant activity (AA= 61.44%) and low concentration of total phenolics (107.11 mg gallic acid 100 g-1 fresh weight)93 2. The pumpkin fruit pulp extracts showed considerable differences in antioxidant activity (AA = 59.28-79.46%) when it was calculated by