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العنوان
ADVERSE EFFECTS OF ADMINSTRATION OF
SOME ANTIBIOTICS ON REPRODUCTION IN
EXPERIMENTAL ANIMALS AND
THE POSSIBLE PROTECTIVE
ROLE OF VITAMIN E/
الناشر
Ain Shams university.
المؤلف
ADAWY, MANAL HAMED SHAKER MOHAMED.
هيئة الاعداد
مشرف / Farouk Abdalla El-Sayed Khalil
مشرف / Ahmed Mohamed Shehata
مناقش / Mosaad Attia Abdel Wahab
مناقش / Hanafy Embaby El-Sobhy
الموضوع
Antibiotics .Oxidative stress Reproduction. Female albino rats. Antibiotics .Oxidative stress Reproduction. Female albino rats.
تاريخ النشر
2011
عدد الصفحات
p.:115
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
1/1/2011
مكان الإجازة
جامعة عين شمس - كلية الزراعة - Animal Physiology
الفهرس
Only 14 pages are availabe for public view

from 133

from 133

Abstract

This study was conducted to investigate the adverse effects of some antibiotics (amoxicillin and doxycycline) on some reproductive aspects and their relation to the oxidative stress in albino rats. br The results showed that administration of both antibiotics caused a decline in some antioxidant parameters (GSH and vit C) and an increase in some oxidative stress markers (MAD, GSSG and nitric oxide) in serum which were alleviated by the addition of vit E or improved by an administration of vit E alone. Treatment with antibiotics reduced serum estradiol and elevated serum progesterone but administration of vit E alone increased estradiol and progesterone. The levels of LH and FSH were decreased by the administration of antibiotics (alone or with vit E) but increased by vit E alone. The effects of antibiotics or vitamin E were more obvious for serum FSH than for LH serum levels. The estrous cycle and the luteal phase were prolonged by antibiotics treatment, while vitamin E alone prolonged follicular phase. br Antibiotics administration decreased ovulation rate, early embryonic survival rate, litter size and live body weight while they increased embryonic mortality rate at mid-pregnancy. Administration of vit E alone enhanced growth of newborn rats, decreased embryonic mortality rate and shortened the duration lasted -#102;-#114;-#111;-#109; male exposure to female and parturition. br In conclusion, the oxidative stress which may be resulted -#102;-#114;-#111;-#109; of antibiotics daily administration has deleterious effects on growth and reproduction of female albino rats and these harmful effects could be alleviated by daily administration of vitamine.