الفهرس 
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Abstract
Buccal delivery of drugs provides an attractive alternative to the oral route of drug administration particularly in overcoming deficiencies associated with latter mode of dosing.
Through buccal drug delivery, it is possible to realise mucosal (local effect) and transmucosal (systemic effect) drug administration.
Systemic administration using antimicrobials such as metronidazole and non steroidal anti-inflammatory drugs (NSAID) such as ketorolac tromethamine have been useful in treating oral cavity conditions, but repeated and long term use of systemic drugs is fraught with potential danger.
Metronidazole has often been chosen for periodontal treatment because of its selective efficacy against obligate anaerobic rods and spirochetes in the subgingival microflora.
Ketorolac tromethamine is one of the NSAID’s that has not been widely exploited by many researches for the use in the treatment of the oral cavity conditions but that have shown great success in this field.
The present thesis aimed at developing and evaluating suitable drug delivery system for local administration of metronidazole and ketorolac tromethamine with the aim of improving patient compliance, therapeutic efficacy, reduced dosage regimen and targeted drug action with mucoadhesive polymeric systems to overcome disadvantages associated with conventional preparations.
The work in this thesis is divided into two parts:
Part I:
Formulation and evaluation of Metronidazole bucoadhesive erodible disks.
The objective of this part was to develop mucoadhesive erodible disk containing low dose of metronidazole for possible localization of the antibiotic in the buccal cavity to effectively act on periodontal pathogen and treat different periodontal diseases.
Different bucoadhesive erodible disk formulations were prepared for this purpose using sodiumcarboxymethylcellulose and hydroxypropylmethylcellulose K4M either alone or in blend of different ratios in order to achieve sustained drug release, mannitol was also added in different concentration to impart good taste and erosion. The prepared disks were evaluated for their in-vitro drug release, in-vitro bioadhesion strength, in-vitro residence time, surface pH, disk thickness, disk hardness, friability, as well as in-vivo drug release, in-vivo residence time, microbiological evaluation and accelerated stability testing on selected formulation.