الفهرس 
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Abstract
Lung cancer is one of the most life-threatening cancers worldwide. Treatment for this cancer includes combinations of chemotherapy and radiotherapy. However, side effects of these therapies are limiting their efficacy, so alternative therapies are now emerging. Many of such alternative treatments are based on nutrition. Therefore, this study was aimed to evaluate protective and therapeutic effects of a specific mixture, containing vitamin C, lysine, proline, epigallocatechin gallate and zinc as well as alpha-1-antitrypsin protein on lung tumorgenesis induced by benzo(a)pyrene carcinogen in 130 male Swiss albino mice. The mice were divided into two main experiments, experiments (1) had 80 mice injected with 100 mg/kg b(a)P and lasted for 28 weeks, while experiment (2) had 50 mice, injected with 400 mg/kg b(a)P and lasted for 16 weeks. Each experiment divided into five groups, group (I) received vehicle, group (II) received the protector mixture, group (III) received the carcinogen, group (IV) received the protector together with the carcinogen simultaneously and group (V) received the carcinogen then the protector consecutively. Biochemical indicators of tumorgenesis such as TSA, TBARS, VEGF, α2-MG, HYP as well as elastase and gelatinase activities showed significant elevation in group (III) in the two experiments in comparing to group (I). Administration of the protector in group IV and group V causes significant decrease in such parameters when compared with group III in the two experiments. This indicates that the present protector mixture has the ability to suppress neoplastic alteration by maintaining TSA status, inhibiting lipid peroxidation, halting angiogenesis, arresting matrix degradation and strengthen connective tissue. These results were confirmed by histopathological investigation. Moreover, it was found that B(a)P dose has a great effect on the changes occurred in the lung, where, many parameters were greatly altered in experiment (2) than in experiment (1). Furthermore, the present mixture was found to have more protective action rather than therapeutic action as its action on almost all parameters is more effective in group IV than in group V.
Key words: Lung tumergenesis, benzo(a)pyrene, vitamin C, lysine, proline, epigallocatechin gallate, zinc , alpha-1-antitrypsin.