الفهرس 
LiverOnly 14 pages are availabe for public view
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Abstract
Several scientific evidences highlighted that incorrect dietary choices combined to modern lifestyle can cause chronic metabolic imbalances that lead to a series of diseases, such as cardiovascular diseases, obesity, type 2 diabetes, osteoporosis, various inflammatory diseases and types of cancer. On the other hand, the relevance of human nutrition in the maintenance of the good healthy status is an ancient issue as in the year 500 BC Hippocrates said that ‘‘Food is medicine, and medicine is food’’. Chronic liver damage is, in fact, a worldwide common pathology, characterized by an inflammatory and fibrotic process that leads to a progressive evolution from chronic hepatitis to cirrhosis and hepatocellular carcinoma (HCC). The prevalence of non-alcoholic fatty liver diseases (NAFLD) is of 50–90% in obese population, 70% in type II diabetics and till 100% in subjects affected by both diseases. Polyphenols present abundantly in vegetables and fruits and have been recognized as functionally active molecules, possessing antioxidant, anticancer and antimutagenic properties, as well as exerting protective effects against several diseases.the study will systematically evaluate the safety and efficacy of dried grape leaves and their water and ethanol extracts ingestion in cci4 induced hepatotoxicity in rats.