الفهرس 
Anatomy of the breastOnly 14 pages are availabe for public view
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Abstract
The term EIC applies to an invasive ductal
carcinoma in which intraductal cancer is prominently
present within the tumor or in sections of grossly normal
adjacent breast tissue. Although EIC had previously been
considered a contraindication to BCT, it is only a risk factor
for local recurrence when the margins of resection are not
evaluated (Harris, 1996) Compared with EIC-negative
cancers, those with EIC-positive margins have a higher rate
of true local recurrence, but not new ipsilateral primaries,
contra-lateral breast tumors, or an increased likelihood of
distant relapse. These data reflect the higher incidence of
multifocality and residual cancer following excision of
tumors with an EIC (Holland et al., 1990)
As an example, in one study of 214 women who
underwent mastectomy with detailed histological
evaluation of the specimen, EIC-positive tumors were
more likely to have prominent residual intraductal
carcinoma at least 2 cm beyond the edge of the primary
tumor (30 versus 2 percent in EIC-negative cancers)
(Holland et al., 1990)
In contrast, women with EIC and negative resection
margins do not have an increased risk of ipsilateral
recurrence following BCT (Gage et al., 1996)
Therefore, routine assessment of the margins of
resection is an important component of the histological
evaluation in women undergoing BCT, particularly those
with an EIC. A larger breast resection in such women might
result in a smaller residual tumor burden and a reduced
risk of ipsilateral recurrence following RT.