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Abstract The main aim of this essay is to highlight where we stand in the genetic research of OCD in order to make early diagnosis even prevention programs and to treat more successfully. The choice of the early-onset OCD to be focused on as it is common subtype and it represents an endophenotype which confirms the genetic basis of the disorder. This essay reviewed recent genetic studies of OCD. There is no doubt that this disorder has genetic basis but the exact mechanism to explain this inheritence has to be elucidated as no one set of genes responsible for its inheritance and the low statistical power of the genome wide scan studies. The first chapter gives idea about early-onset OCD and the demographic importence of the subject. The studies reviewed in chapter two propose several different pathways through which neurochemical dysfunction may lead to the development of OCD The studies reviewed in chapter three provide evidence for a genetic predisposition to develop OCD in addition to linking the genes implicated in the etiology of OCD with the neurochemical dysfunction. Chapter four summarized how to face the proplem of heterogencity of OCD on the genetic research of the disorder by studying the endophenotypes and biological markers of the disorder |