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العنوان
Updated view in genetics of obsessive compulsive disorder with focusing on the early-onset subtype /
المؤلف
Sonbol, Hassan Mohammed Ahmed.
هيئة الاعداد
باحث / Hassan Mohammed Ahmed Sonbol
مشرف / Zeinab Abu El-Fotoh Gomaa
مشرف / Salwa Salah Tobar
مشرف / Eman Abd El-Moaty El-Sheshtawy
الموضوع
Obsessive-compulsive disorder-- Diagnosis.
تاريخ النشر
2012.
عدد الصفحات
117 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأعصاب السريري
تاريخ الإجازة
1/1/2012
مكان الإجازة
جامعة المنصورة - كلية الطب - Department of Neuropsychiatry
الفهرس
Only 14 pages are availabe for public view

from 147

from 147

Abstract

The main aim of this essay is to highlight where we stand in the genetic research of OCD in order to make early diagnosis even prevention programs and to treat more successfully.
The choice of the early-onset OCD to be focused on as it is common subtype and it represents an endophenotype which confirms the genetic basis of the disorder.
This essay reviewed recent genetic studies of OCD. There is no doubt that this disorder has genetic basis but the exact mechanism to explain this inheritence has to be elucidated as no one set of genes responsible for its inheritance and the low statistical power of the genome wide scan studies.
The first chapter gives idea about early-onset OCD and the demographic importence of the subject.
The studies reviewed in chapter two propose several different pathways through which neurochemical dysfunction may lead to the development of OCD
The studies reviewed in chapter three provide evidence for a genetic predisposition to develop OCD in addition to linking the genes implicated in the etiology of OCD with the neurochemical dysfunction.
Chapter four summarized how to face the proplem of heterogencity of OCD on the genetic research of the disorder by studying the endophenotypes and biological markers of the disorder