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Abstract In line with the recent approach of using essential oils and antimicrobial agents in combination as a strategy to overcome the problems of resistance and side effects associated with conventional antimicrobial agents, in the present study, 20 essential oils were screened for antimicrobial potential against reference strains of Gram-positive bacteria (Staphylococcus aurcusi, Gram-negative bacteria (Escherichia coli), and yeast (Candida albicans). Most of the selected essential oilsshowed antimicrobial activity with varying magnitudes. The most effective essential oils were chosen for the rest of tests on clinical isolates. The MICs of chamomile, cinnamon, cumin, parsley, rose red, and wild basil oils against S. aurcus (n= 13), Ps. aeruginosa (11= 15), K. pneutnoniae in= 15), E. coli (11= 15), and Pr. mirabilis (11=25) and of cinnamon, clove, cum in, lemon, rose red, and wild basil oils against C. albicans (11=6) were determined, and MIC values data, indicating MICsII, MICl)o, and geometric mean were calculated. Rose red, wild basil, cumin, and cinnamon oils were the most active antibacterials with rose red oil had interesting activity against Proteus mirabilis (40% of isolates presented MIC values :S8 ug/rnl). S. aurcus was the most susceptible bacteria while Pr. mirabilis was the least. On the other hand, wild basil oil and lemon oilexhibited the highest and the least active against C. albicans, respectively. |