الفهرس | Only 14 pages are availabe for public view |
Abstract In the last decade chemists started to use ultrasound waves as a source of thermal and mechanical energy in reactions which need high conventional heat. Since intense ultrasonic waves traveling through liquids generate small cavities that enlarge and implode, creating tremendous heat and pressure sufficient for completing the organic reactions. Sonochemistry is a new methodology used for improving the traditional reactions that use expensive reagents, long reaction times, high temperatures, unsatisfactory yields besides it is friendly and non-toxic to environment. In the present investigation, we wish to report the ultrasound induced 1,3- dipolar cycloaddition reactions of 1-Cyanomethyl pyridinium-3-olate (2) with numerous 2π-electron addends with the view to synthesis many azabicyclo heterocycles which have therapeutic interest. The structures of the new obtained products were established by use of Infra red, Mass spectra and 1HNMR, spectral evidence. The biological activities of some of the isolated new products were investigated. |