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العنوان
QUANTIFICATION OF CHROMOSOMAL t (14;18) IN B – CELL NHL PATIENTS USING REAL – TIME PCR
الناشر
Cairo Universty
المؤلف
SARAH , ADEL LABIB YOUNAN
هيئة الاعداد
مشرف / Nesrine, Mohamed El Gharbawi
مشرف / Hamdy, Abd El Azeem Abd El Monem
مشرف / Mervat ,Saad El Ansary
مشرف / SARAH , ADEL LABIB YOUNAN
تاريخ النشر
2007
عدد الصفحات
100
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الطب (متفرقات)
تاريخ الإجازة
1/1/2007
مكان الإجازة
جامعة القاهرة - كلية الطب - Clinical and Chemical Pathology
الفهرس
Only 14 pages are availabe for public view

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from 348

Abstract

One of the common aberrations seen in non-Hodgkin’s lymphoma (NHL) is t(14;18)(q32;21.3). The aim of this work is to study the incidence and quantity of t(14;18) in B-NHL. 33 patients with B-NHL and 10 controls with non-neoplastic lymphoid tissue disorder were tested for quantitation of t(14;18) by real-time quantitative PCR (RQ-PCR). The incidence of t(14;18) was 6.1% among NHLs, 14.3% among follicular lymphomas (FLs), 5.6% among diffuse large cell lymphomas (DLCLs) and 10% among control group. The value of relative quantification for patients was (1.20 and 0.85), while for control case was (0.6). RQ-PCR is a sensitive and specific procedure. It is an ideal tool for follow-up and quantification of minimal residual disease (MRD).
Keywords:
Real-time PCR, t(14;18).