الفهرس 
ChemicalOnly 14 pages are availabe for public view
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Abstract
As a part of the program aimed at the development of new
nucleoside derivatives with potential biological activities, we describes
herein the new method for the construction of 3-aminoindole nucleosides
of 2-acetamido-2-deoxy-D-glucose and its antiviral activity against
hepatitis B virus (HBV).
The ease of accessibility and the biological significance of 2-
acetamido-2-deoxy-D-glucose have prompted us to use this aminosugar
as a starting material in Sasaki glycosylation reaction
.
Thus, the sodium
salt of indole derivatives (1a-c) was condensed with 2-acetamido-1-
chloro-3,4,6-tri-
O
-acetyl-2-deoxy-D-glucose (2) in dry DMF. The
reaction was proceeded at 90oC to give the desired 1-(2-acetamido-
3,4,6-tri-
O
-acetyl-2-deoxy--D-glucopyranosyl)indoles (3a-c) (Scheme
1).