الفهرس 
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Abstract
Lead is a ubiquitous element in the environment causing oxidative burst in the exposed individuals leading to liver damage. Antioxidants in garlic oil have long been known to reduce the free radical-mediated oxidative stress. The present study was undertaken to examine the inhibitory effect of garlic oil on lead acetate induced hepatotoxicity in young male rats. Male albino rats weighing 50±5g were assigned in four groups, 12 rats each, as follows: control, garlic oil (1ml/kg), lead acetate (40mg/kg) and garlic oil +lead acetate groups. Each group was then investigated after one and two months. The results indicated that lead exposure caused a significant decrease in the mean body weight gain, liver, kidney and femur bone relative weight and total protein in liver, kidney and femur bone and serum. In contrast, a significant increase in alkaline and acid phosphatase activities was recorded in serum and liver, kidney and femur bone. And also, a significant decrease in Ca, Ph and Mg concentration in serum and femur bone (except for serum Mg which exhibited a significant increase). Furthermore, increased liver, kidney and femur bone oxidative stress marker; malonylaldehyde and serum &liver, kidney and femur bone total lipid were also noted after lead exposure. Concerning the antioxidant status, liver, kidney and femur bone reduced glutathione; superoxide dismutase; catalase & glutathione S transferase were significantly inhibited. On the other hand, co-administration garlic oil succeeded to improve the biochemical parameters of liver, kidney and femur bone function, oxidative stress and antioxidant status towards the normal values. In conclusion, the present results indicated that garlic oil has the ability to protect the liver from the damaging effects of lead exposure. This protection might be attributed to the antioxidative power of garlic oil components against lead- induced oxidative stress and enhancing the hepatic, renal and femur bone antioxidant system.