الفهرس | Only 14 pages are availabe for public view |
Abstract Acute coronary syndromes (ACS) are multifactorial and occur in response to inflammation, plaque rupture with subsequent thrombosis, progressive mechanical obstruction, and dynamic obstruction. Biomarkers are being used as tools to identify subgroups of patients with ACS who are at increased risk for subsequent cardiovascular events. Myoglobin can be detected in the serum as early as two hours after myocardial necrosis begins. Cardiac troponin is a well established biomarker for diagnosis and prognosis of ACS. Patients with elevated BNP or NT-proBNP are at significantly increased risk for subsequently developing heart failure. CRP in addition to BNP and troponin appear to provide some additional value in the prognosis of ACS. MPO is responsible for fibrous cap disintegration making it a marker of plaque instability and inflammation. |