الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Considering the several literatures enlightening the antiviral nature of the pyrazole ring, a series of pyrazole derivatives conjugated to a moiety having antiviral activity was synthesized and in vitro evaluated for their antiviral activity.
In the present investigation, new series of 3-methyl-1,5-diphenylpyrazole derivatives having different substitutions at the 4-position of the pyrazole ring was prepared.
In order to obtain the target compounds, different chemical pathways were adopted and found to be successful. In the present study, forty one novel compounds that are not mentioned in the available literature were synthesized. The formation and purity of the newly synthesized compounds were checked by TLC, and their structures were elucidated through elemental microanalyses, IR, 1H-NMR and mass spectroscopy.
Thirty six compounds of the newly synthesized ones were subjected to in vitro antiviral assay in order to screen their antiviral activity and the degree of cytotoxicity using Herpes simplex type 1(HSV-1) grown on Vero African green monkey kidney cells. Six compounds showed strong antiviral activity, six exhibited moderate activity, while three compounds showed weak activity.