الفهرس 
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Abstract
A biopharmaceutics drug classification scheme for correlating in-vitro drug product dissolution and in-vivo bioavailability is based on recognizing that drug dissolution and gastrointestinal permeability are the fundamental parameters controlling rate and extent of drug absorption. Class II drugs are those with low solubility and high permeability for which the dissolution profile must be clearly defined and reproducible. For this class of drugs, the rate of oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Drugs in this class may be expected to have variable absorption rates due to many formulation and in-vivo variables that can affect the dissolution profile. Also, in-vitro I in-vivo correlation is expected if in-vitro dissolution rate is similar to in-vivo dissolution rate. Celecoxib, belongs to a class of agents that selectively inhibits cyclo-oxygenase 2 (COX-2) enzymes, it exhibits anti-inflammatory and analgesic activity. Celecoxib is categorized as a class II drug and has a poor dissolution in aqueous media.