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Abstract Chlorpyrifos methyI (Reldan) and pirimiphos methyI (Actellic) are the two most widely used organophosphate (OP) grain protectants in Egypt. These compounds remain two of the most widely used insecticides globally in agriculture and public health, despite restrictions placed on some of its domestic use by united states environmental protection agency (EPA). In this study , the risk assessment of the two pesticides was investigated in the Japanese quail (Coturnix coturnix japonica). The potentials of these compounds in mitigating biochemical and histological alterations induced by dietary subacute exposure to subacute exposure to sublethal doses of each compound were determined based on the the organization for economic cooperation and development (OECD, 1996) workshop report. This is in view of the role of biochemical and histological parameters as a tool in evaluating and predicting the toxicological risks of pesticides in Egypt. Therefore, single-dose acute oral and short-term subacute dietary toxicity tests (5- and 21-day subacute exposure) with the Japanese quail were carried out to provide critical information on the potential hazard of selected pesticides to wild populations. The subacute test present graded doses, 1/10, 1/100 and 1/100 LC50 of a pesticide in the diet for a specified duration, 5- and 21-days. This feeding trial provides an evaluation of response to repeated chemical exposures as may be encountered in the field. |