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Abstract The aim of study to study the effects of probiotic on the plasma lipid profile of hypercholesterolemic rats .: Grape juice, dates jam and rayb milk were supplemented with different levels (106,107, 108) CFU/m1 of probiotics (Lactobacillus acidophilus and Bijidobacterium), then these products evaluated organoleptically. The best results was from the level 108 CFU/m1 which was used in a biological study. Serum (total cholesterol, tota1lipids, trig1ycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, kidney and liver functions) were measured. Both Bijidobacterium and Lactobacillus acidophilus significantly decreased (P<O.05) serum total cholesterol, Triglycerides, total lipids, LDL-C, and VLDL-C and significantly increased (p<0.05) serum HDL-C compared to the control group. It was observed that Bifidobacterium was more effective than Lactobacillus acidophilus, also, feeding a combination of Lactobacillus acidophilus and Bifidobacterium has a better effect than using of a single of them. The results referred that, all kinds of cures with different probiotics didn’t affect the function of liver and kidney function. So that, grape juice, dates jam and rayb milk supplemented with probiotics bacteria strains had a cholesterol-lowering effect in hypercholesterolemic rats. |