الفهرس 
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Abstract
An abortion is the removal or expulsion of an embryo or fetus from the uterus, resulting in or caused by its death. This can occur spontaneously as a miscarriage, or be artificially induced by chemical, surgical or other means. ”Abortion” can refer to an induced procedure at any point during human pregnancy; it is sometimes medically defined as either miscarriage or induced termination before the point of viability ( Merriam Webster’s Medical Dictionary, 2006)
Medical abortion is effective in the first trimester of pregnancy, medical (sometimes called chemical abortion), or non-surgical abortions comprise 10% of all abortions in the United States and Europe. Combined regimens include methotrexate or mifepristone, followed by a prostaglandin (either misoprostol or gemeprost: misoprostol is used in the U.S.; gemeprost is used in the UK and Sweden.) When used within 49 days gestation, approximately 92% of women undergoing medical abortion with a combined regimen completed it without surgical intervention. (Spitz et al., 1998) Misoprostol is a synthetic prostaglandin E1-analogue approved and marketed for prevention and treatment of gastric ulcers associated with nonsteroidal anti-inflammatory drugs. It is also an effective uterotonic agent. Many randomized trials have shown its efficacy and safety for indications such as induction of labor, first and mid trimester abortion, and management and prvention of postpartum hemorrhage, (Goldberg et al., 2001).
Misoprostol is absorbed rapidly after oral and rectal administration, does not need special storage conditions, can be used in hypertensive patients and is relatively inexpensive (Gaud et al., 1992. Recent pharmacokinetic study suggested that the bioavailability of misoprostol after sublingual administration was higher than those after oral or vaginal administration(Tang et al., 2002).
This study was conducted at El-Minia University, a total of 250 women between 12 and 28 weeks of gestation who were scheduled for pregnancy termination, recruited from attendants of the out-patient clinic of Obstetrics of Suzan Mubark University hospital, were included in this study, starting on December 2008 to December 2009. Cases were randomly divided into two matched groups, 125 women each, Group A and Group B. the method of randomization was simple, as those admitted in even days were in group A , while those admitted in odd days were in Group B.
For the studied cases in Group B a well prepared sterile and stable solution was instilled into the extra-amniotic space. The ultimate outcome variables were recorded and statistically analyzed. The results proved that this mode of inducing abortion in indicated terminatioln of pregnancy is safe , rapid and carries the risk of lower adverse eddects. Further larger scale studies are needed to support the results of this clinical trial.