الفهرس 
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Abstract
Transforming growth factor (TGF-β1) is a crucial mediator in the pathogenesis of
inflammatory disease. TGF-β1 gene polymorphism may reflect or control the severity
and progression of various immunologic phenomena associated with the diseases. We
investigate the role of the TGF-β1 gene polymorphisms located at codons 10 and 25 in
the genetic predisposition to type 2 diabetes (T2D) and in diabetic nephropathy (DN) in
Egyptian patients. A case control study was done for 99 unrelated Egyptian patients with
T2D (50 DN- and 49 DN+) and 98 age- and sex-matched healthy controls. TGF-β1
T869C (codon 10) and G915C (codon 25) polymorphism detection was done by
amplification refractory mutation system method (ARMS). DN+ patients were younger in
age and with higher levels of body mass index (BMI), serum triglycerides, serum
creatinine, and lower serum albumin than DN- patients. Moderate and bad grades of
diabetic control were associated with diabetic nephropathy (P<0.001). The TGF-β1
(T869C) C allele, TC and TC+CC genotypes were significantly higher in patients and the
T allele, TT genotype were significantly higher in controls (Pc<0.001). The TGF-β1 TC
genotype was associated with diabetic nephropathy (Pc<0.05). On the other hand, non
significant differences were detected between T2D patients and controls in the
frequencies of TGF-β1 (G915C) alleles and genotypes. Taken together, our data showed
that the TGF-β1 codon10 C allele, and C allele-containing genotypes may be
susceptibility, and T allele/TT genotype may be protective factors for T2D and DN+
complications.
ACKNOLEDGMENT
(First.