الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Iron deficiency is the most common nutritional disorder affecting at least one third of world’s population. Aim of the work to review the literature regarding medical complications beyond iron deficiency anemia regarding the role of iron therapy in treatment of these complications. There are multiple theories explaining pathogenesis of iron deficiency anemia, the recent theory is increased red cell porphyrin, which inhibits ferrochelatase enzyme, thus further inhibiting heme synthesis. This eventually leads to decreased hemoglobin synthesis and anemia of iron deficiency ensues. Besides this, decreased activity of ribonucleotide reductase and pyruvate dehydrogenase enzymes has also been demonstrated in iron deficient individuals, which explains decreased DNA synthesis and impaired cellular oxidation respectively.