الفهرس 
1. IntroductionOnly 14 pages are availabe for public view
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Abstract
Propolis and its extract have antioxidant properties. The present work was conducted to study the effect of propolis on oxidative - antioxidative status of diabetic rats. Diabetes was induced experimentally in rats by intra- peritoneal injection of Alloxan in a dose of 150 mg/kg body weight.
Various nutritional and biochemical parameters were estimated. Propolis was given to diabetic rats, orally, at five levels (25, 50, 100, 200 and 400mg/kg bwt) daily for 40 days after alloxan injection.
The values of blood glucose, cholesterol, triglycerides (TG), Low - density lipoprotein- cholesterol (LDL-c), Very Low - density lipoprotein - cholesterol (vLDL-c), Atherogenic index (AI), Got, GPT, ALP, creatinine, uric acid and urea significant increased for positive control (+) compared with negative control (-), but (HDL-c) was significant lower.
Moreover, liver tissue MDA was markedly increased while SOD, GSH, GST and CAT were significant decreased. Oral administration of propolis in doses of (25, 50, 100, 200 and 400 mg/kg bwt) improved organs weight, body weight again (BWG), Serum glucose, lipid profile, renal function tests, liver function and malondialdehyde (MDA). liver glutathione (GSH), super oxide dismutase (SOD), glutathione-stransferase (GST) and catalase (CAT) were significantly increased while MDA was markedly reduced. These results may suggest a strong antioxidant effect of propolis which can ameliorate oxidative stress in a dose - dependent manner.
Key words: Proplois; diabetes; oxidative stress.