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Abstract Liver is a vital organ play a major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the pharmaceutical industry and drug regulatory agencies. Liver cell injury caused by various toxic chemicals (certain anti-biotic, chemotherapeutic agents, carbon tetrachloride (CCL4), thioacetamide (TAA) etc. Chronic hepatic diseases stand as one of the foremost health troubles worldwide, with liver cirrhosis and drug induced liver injury accounting ninth leading cause of death in western and developing countries. Therefore, treating liver diseases with plant-derived compounds which are accessible and do not require laborious pharmaceutical synthesis seems highly attractive. Many plant components are now synthesized in large laboratories for use in pharmaceutical preparations Nigella sativa has been used for medicinal purposes for centuries; it has been traditionally used for a variety of conditions and treatments. Foeniculum vulgare fixed oil has a potent hepato-protective action against carbon tetrachloride-induced liver fibrosis in rats. So this work aims to study the effect of herbal drugs on liver fibrosis. The process starting by the induction of Carbon tetra Chloride (CCl4) in the liver. |