الفهرس | Only 14 pages are availabe for public view |
Abstract The main purpose of this study is to display the relationship between levels of serum sialic acid, L-fucose as well as uronic acid and the state of the liver and kidney, under certain experimental conditions, in order to find whether these chemicals can be used as biological markers in some cases of liver and kidney diseases. Therefore, the conventional parameters indicating liver and renal functions have been also determined under the same experimental conditions. The present study has been extended to investigate and analyze the new suggested chemical markers in blood of human especially those suffering from liver cirrhosis, virus C infected subjects and those suffering from renal failure. The experimental animals were divided into six groups, ten rats in each group as following: G1: Animals of this group received 0.4 ml olive oil intraperitoneal injection (i.p.) on day 1 and day 7 of the experiment and served as control group for G2 group. G2: Each rat of this group received single dose of CCl4 (CCl4+ olive oil in 1:1 ratio: 2 ml/kg body weight) (i.p.) on day 1 and day 7 of the experiment. G3: Each rat of this group received 0.4 ml olive oil (i.p.) on day 1, 7 and day 14 of the experiment and served as control group for G4 group. G4: Animals of this group received single dose of CCl4 (CCl4 +olive oil in 1:1 ratio: 2 ml/kg body weight) (i.p.) on day 1, 7 and day 14 of the experiment. G5: Animals of this group received sterile saline solution only (i.p.) for 8 consecutive days, and served as control for G6 group. Summary and Conculsion - 111 - G6: Animals received gentamicin sulphate (100 mg/kg body weight) (i.p.) once daily for 8 consecutive days |