الفهرس | Only 14 pages are availabe for public view |
Abstract Glutathione is the master antioxidant of the body. Clinical studies demonstrated that glutathione has the potential to fight almost any disease, particularly those associated with aging, since free radical damage is the cause of many of the diseases. Nevertheless, glutathione tried for the treatment of a whole host of conditions, including cancer, high blood pressure, Parkinson’s disease, Alzheimer’s disease, cataracts, and male infertility 2. AIM OF STUDY The main objective of present investigation was studying the therapeutic effects of dietary sources of glutathione on experimental rats pretreated with different disease stimulators. 3. MATERIALS AND METHODS 1. Investigated Samples: Investigated samples are the precursors of glutathione such as whey protein concentrated (WPC) and yeast powder, which contain high level of sulphur containing amino acids and help to maintain optimal glutathione levels 2. Experimental Animals (Rats): Adult male albino rats (Sprague–Dawley Strain) weighing 170-200 g at age 14-16 weeks, and also elderly male albino rats, weighing 360-390 g at age 1 year were use in this investigation. 3. Induction of Different Diseases in Experimental Animals :3.1. Induction of diabetes mellitus in rats: Rats pwere treated subcutaneous injection with Alloxan monohydrate which was dissolved in sterilized distilled water and given at a dose of 150 mg/kg body weight. 3.3. Induction of acute renal failure in rats: Rats were treated with subcutaneous administration using 50% (w/v) glycerol in 0.9 % saline at 10 ml/kg body weight. |