الفهرس 
Fetal GrowthOnly 14 pages are availabe for public view
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Abstract
In the present study, we aimed to asses resistin in face of IGF complex in cord blood of full term SGA newborns and investigate its possible relation to growth .We assessed for levels of cord blood resistin ,insulin and IGF-I in SGA and AGA as hormones involved in fetal growth.
This study was performed on (50) neonates delivered at the labour word of maternity hospital of Ain Shams university during the period from May 2009 to January 2010.
Two groups were included in the study:
1-The study group: included 30 full term SGA newborns with male: female ratio 3:2, mean birth weight 2.307 ± 0.244 (kg) and mean gestational age 37.7 ± 0.95 (weeks).
We excluded preterms, newborns with respiratory distress, hypoxic ischemic encephalopathy, genetic abnormalities, congenital infection, neonatal sepsis, infants of diabetic mothers and maternal intake of hormones during pregnancy.
2-The control group: included 20 healthy full term AGA newborns as the control group with male: female ratio 1:1, mean birth weight 3.458 ± 0.323 (kg) and mean gestational age 38.65 ± 1.23(weeks).
They obeyed the exclusion criteria of the study group and were sex matched with the study group.
All cases were subjected to detailed history taking ,clinical evaluation, detailed anthropometric assessment and laboratory investigation including cord blood levels of glucose, resistin, insulin and IGF-I.
Cord blood levels of glucose, resistin, insulin and IGF-I were significantly lower among SGA group compared to AGA.
Significant difference between SGA and AGA were detected as regards all anthropomertric measures including BW, length, OFC, ponderal index and SFT (biceps, triceps, suprailiac and subscapular) all being significantly lower among SGA.
The present study showed that there was significant difference between cases and controls as regards maternal preeclampsia and multiple gestations being more common among mothers of SGA.
At the same time it demonstrated that there were non significant difference between cases and controls as regards maternal age at deliver, socioeconomic state, parity, neonatal sex and mode of delivery.
Possible relation of the studied hormones to different anthropometric parameters of growth was investigated showing that:
There was significant negative correlation between cord blood resistin and BW, length in SGA.
There was significant positive correlation between cord blood IGf-I and BW, length among cases. Also significantly lower BW was detected among SGA babies with low cord bl. IGF-I compared to those with normal cord bl. IGf-I.
The present study did not find significant correlation between BW and cord bl. Insulin level neither in SGA nor in AGA.
Relations of the studied hormones to other factors that may affect fetal growth were also investigated showing that:
Lower insulin levels were associated with multiparity and lower IGF-I levels were associated with preeclampsia otherwise; neither sex, mode of delivery, multiple pregnancy, nor socioeconomic status of mothers was related to cord blood level of the studied hormones.
The interrelation of insulin and IGF-I was demonstrated by the present study as they were significantly positively correlated in AGA .Also ,insulin was significantly lower in SGA with lower IGF-I compared with that with normal IGF-I.
The present study found significant negative correlation between resistin and other hormones involved in fetal growth namely IGF-I and insulin in SGA. Also significant positive correlation was detected between cord bl. Resistin and GA.