الفهرس 
AtherosclerosisOnly 14 pages are availabe for public view
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Abstract
Atherosclerosis is essentially an inflammatory response to a variety of risk factors and the consequences of this response is leading to the development of cardiovascular disease. It is a systemic disease with focal rupture of vulnerable plaque responsible for major clinical events. Atherosclerosis, the underlying cause of heart attacks, strokes and peripheral vascular disease, accounts for 50 percent of all deaths in Western countries
Cardiovascular diseases include coronary heart disease (heart attacks), cerebro vascular disease. Heart attacks and strokes are mainly caused by a blockage that prevents blood from flowing to the heart or the brain. The most common cause is a build-up of fatty deposits on the inner walls of the blood vessels that supply the heart or brain.
Inflammation plays an important role in atherogenesis and its clinical complications. In recent years, a large number of biomarkers of inflammation have been investigated and have been associated with variant cardiovascular risks
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel inflammation marker. We investigated its association with atherosclerosis and evaluated its role as a comprehensive marker of the cardiovascular events in individuals with cerebral stroke and myocardial infarction. It also plays an important role in inflammation and in atherosclerotic process, which are present in cardiovascular diseases.
Also we investigate hsCRP and its possible role in medication of cardiovascular disease, and study its association with lipoprotein phospholipase A2 in type2 diabetic subjects with cardiovascular events.
The study included 45 subjects divided into 3 groups:
Group I: 15 type2 diabetic subjects presenting with ischaemic stroke.
Group II: 20 type2 diabetic subjects presenting with acute myocardial infarction.
Group III: 10 healthy individuals as a control group.
The results were statiscaly analyzed and we observed the following:
Lipoprotein Phospholipase A2 and highly sensitive C-reactive protein were higher in subjects with acute cardiovascular events(cerebrovscular stroke and acute myocardial infarction) than those healthy individuals among the studied groups and it was statiscaly significant.
There was significant correlation between Lipoprotein Phospholipase A2 and highly sensitive C-reactive protein among cerebrovscular stroke subjects. But there was no significant correlation between Lipoprotein Phospholipase A2 and highly sensitive C-reactive protein in myocardial infarction subject.
Type2 diabetic subjects presenting with cerebrovascular stroke.
Regarding lipoprotein Phospholipase A2, there was a positive significant statistical correlation between the Lp-PLA2 and age (r =0.558), systolic blood pressure (r=0.551) , diastolic blood pressure(r =0.781) , LDL-C (r= 0.600) and hsCRP (r=0.532) with P value < 0.05. There was non significant statistical correlation between Lp-PLA2 and FBS (r=0.050), PPBS (r=0.082), triglycerides (r=0.219) , total cholesterol (r=0.020) and HDL-C (r=0.402) and HbA1C (r=-0.159) with P value > 0.05.
Regarding high-sensitivity C-reactive protein, there was a positive significant correlation between hsCRP, age (r=0.673) and systolic blood pressure (r=0.780), LDL-C (r=0.627) and Lp-PLA2(r=0.532) with p value <0.05 where there was non significant correlation between hsCRP and diastolic blood pressure (r=0.126) FBS (r=0.418), PPBS (r=0.335), HbA1C% (r=0.114) triglycerides (r=0.019), HDL (r=0.122). and total cholesterol (r=0.390) with P value >0.05..
Type2 diabetic subjects presenting with acute myocardial infarction.
Regarding lipoprotein Phospholipase A2, there was a negative significant statistical correlation between the Lp-PLA2 and age ( r=-0.984). There was a positive significant statistical correlation between the Lp-PLA2 and CK- MB(r=0.985), CK(r=0.930) with P value < 0.05 . where there was non significant statistical correlation between the Lp-PLA2 and systolic (r=0.149) and diastolic Blood Pressure (r=0.223), hsCRP (r=-0.218), FBS (r=-0.148), PPBS (r=-0.132), HbA1C (r=-0.116), total cholesterol (r=-0.350), serum triglycerides (r=-0.150), LDL-C (r=0.267), HDL-C (r=-234) with P value >0.05.
Regarding high-sensitivity C-reactive protein, there was a positive significant statistical correlation between hsCRP and serum triglycerides (r=0.630),total cholesterol (r=0.906), and HDL-C (r=957) with P value < 0.05. where there was non significant statistical correlation between hsCRP and age (r=0.202), systolic (r=0.216) and diastolic blood pressure (r=0.094) LDL-C(r=0.240),FBS (r=0.355), PPBS (r=0.359), and HbA1C (r=0.328), Lp-PLA2 (r=-0.216), CK- MB(r=-0.250) and CK(r=-0.237) with p value >0.05.
As regard sensitivity and specificity; it was found that hsCRP is more accurate than lipoprotein phospholipaseA2 (more sensitive and more specific than Lp-PLA2) in medication of cardiovascular events.
As regards Lp-PLA2 and hsCRP in comparison between CT Findings .There was a significant statistical correlation as regards stroke severity with mean Lp-PLA2 (97.80±18.68 )and (137.20± 6.26) for moderate and severe cases respectively and mean hsCRP (10.60±1.78 and (14.60± 0.55 ) for moderate and severe cases respectively; with P value <0.05