الفهرس 
Introduction
1. Childhood ALL: Epidemiology & PathophysiologyOnly 14 pages are availabe for public view
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Abstract
Several studies have demonstrated that IL-10 have been associated with therapy outcome in haematological malignancies. In addition to expressing full-length IL-10, a new splicing-derived IL-10 variant (termed IL-10δ3) can be detected in ALL samples. It is strongly associated with the good prognosis of acute lymphoblastic leukemia (ALL) in children.
Aim of the work:
To detect IL-10 and IL-10 isoform, IL-10δ3, expression and its values in childhood BCP- ALL.
Patients and methods:
samples were collected from 60 pediatric patients with BCP-ALL. The detection of IL-10 and IL-10δ3 were performed by conventional reverse transcriptase polymerase chain reaction (RT-PCR).
The results of this study revealed that:
• Cases expressing IL-10δ3 showed less incidence of relapse compared to patients expressing only IL-10 and/or IL-10 below detection limit.
• cases expressing IL-10δ3 showed more CD34 positivity – with better prognosis- compared to non expressing IL-10δ3.
• Immunophenotyping between cases expressing IL-10δ3 compared to non expressing IL-10δ3 was statistically significant. it is rather a predilection to pro B phenotype with IL-10δ3 expression?!.
• In the analysis of pEFS, patients with IL-10δ3 expression had a significantly better pEFS at five years (P= 0.047).