الفهرس 
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Abstract
Cardiovascular disorders (CVDs) as hyperlipidemia and hypertension and thereby atherosclerosis are the number one cause of death globally. According to the World Health Organization (WHO), 29%of all global deaths are of CVDs. In the recent years clinical and pharmaceutical researchers rediscovered traditionally used phytotherapy as a source for new therapeutical approaches. One of those which capture the interest of scientists is the olive tree. The pharmacological properties of olive oil, the olive fruit and its leaves have been recognized as important components of medicine and a healthy diet because of their main phenolic contents oleuropein. Many experimental studies were conducted to explore Oleuropein’s pharmacological properties, including antioxidant, anti-inflammatory anti-atherogenic, anti-cancer, antimicrobial and antiviral activities, but the clinical data are still very few. The present study aimed to review the impact of the daily administration of oleuropein and the extent of its effects on metabolic syndromes as hyperlipidemia and hypertension and subsequently atherosclerosis to pave the way for its use as a safe and effective antihyperlipidemic and antihypertensive drug.
Twenty eligible mild hypertensive and\or mild hyperlipidimic male patients were chosen and received oleuropein 500mg twice daily. Blood samples were collected from each patient before administration of Oleuropein, after 4 and 6 weeks of treatment.
Lipid profile parameters: Serum total cholesterol (TC) , Serum low density lipoproteins (LDL), Serum high density lipoproteins (HDL) and serum triglycerides (TGs), Oxidative stress parameters: Serum super oxide dismutase (SOD) and Malone dialdehyde (MDA), Liver function
VI parameters: Serum AST and ALT were assessed and blood pressure was measured three times per week.
The obtained data in the present study revealed that there were significant decreases in serum TC, LDL, and TGs and there was no significant change in serum HDL. There was a marked decrease in both the SBP and DBP also. In addition, oleuropein treatment resulted in a marked decrease in serum MDA and a marked increase in SOD activity. However, there was no alteration in the liver enzymes.
It could be concluded that Oleuropein can be used as an antihyperlipidemic drug and is effective in ameliorating or normalizing serum TC and LDL. Oleuropein possesses strong vasodilating properties and hence anti-hypertensive activities. It acts as a potent antioxidant and free radical scavenger, which aids more in ameliorating or normalizing oxidative stress causing both hyperlipidemia and hypertension.