الفهرس 
Chapter I : IntroductionOnly 14 pages are availabe for public view
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Abstract
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6.SUMMARY AND CONCLUSION
The aim of the present study was to elucidate the possible biochemical
and histopathological alterations in lipid and selected organ function
profiles that may result from continuous treatment with sildenafil in normal
albino rats and those rendered hyperlipidemic by long term
supplementation of fat and cholesterol-enriched diet.
To achieve this aim, the following experimental design was applied:
Acclimatized rats were divided into seven groups; each consists of ten
animals which were treated differently as follows:
GROUP I : Rats were fed on normal diet and received no drugs;
kept as negative control.
GROUP II : Rats were fed on cholesterol and fat-enriched diet and
received no drugs; kept as positive control for all experimental groups.
GROUP III : Rats were fed on normal diet and received sildenafil
after 30 days from the start of the experiment; kept as negative treated
group.
GROUP IV : Rats were fed on cholesterol and fat-enriched diet and
received sildenafil after 30 days from the start of the experiment; kept
as positive treated group.
GROUP V : Rats were fed on cholesterol and fat-enriched diet and
received sildenafil from the start of the experiment; kept as concurrent
treatment group.
GROUP VI : Rats were fed on cholesterol and fat-enriched diet and
received atorvastatin after 30 days from the start of the experiment;
kept as a standard treated group.
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GROUP VII : Rats were fed on cholesterol and fat-enriched diet and
received EZE after 30 days from the start of the experiment; kept as
standard treated group.
Blood samples were taken for biochemical analysis and tissue
samples were taken for histopathological examination.
The following results were obtained:
1- Sildenafil significantly decreased the serum total lipid concentration
of rats fed on fat- and cholesterol-enriched diet. However,