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Abstract ( 99 ) 6.SUMMARY AND CONCLUSION The aim of the present study was to elucidate the possible biochemical and histopathological alterations in lipid and selected organ function profiles that may result from continuous treatment with sildenafil in normal albino rats and those rendered hyperlipidemic by long term supplementation of fat and cholesterol-enriched diet. To achieve this aim, the following experimental design was applied: Acclimatized rats were divided into seven groups; each consists of ten animals which were treated differently as follows: GROUP I : Rats were fed on normal diet and received no drugs; kept as negative control. GROUP II : Rats were fed on cholesterol and fat-enriched diet and received no drugs; kept as positive control for all experimental groups. GROUP III : Rats were fed on normal diet and received sildenafil after 30 days from the start of the experiment; kept as negative treated group. GROUP IV : Rats were fed on cholesterol and fat-enriched diet and received sildenafil after 30 days from the start of the experiment; kept as positive treated group. GROUP V : Rats were fed on cholesterol and fat-enriched diet and received sildenafil from the start of the experiment; kept as concurrent treatment group. GROUP VI : Rats were fed on cholesterol and fat-enriched diet and received atorvastatin after 30 days from the start of the experiment; kept as a standard treated group. ( SUMMARY ) ( 100 ) GROUP VII : Rats were fed on cholesterol and fat-enriched diet and received EZE after 30 days from the start of the experiment; kept as standard treated group. Blood samples were taken for biochemical analysis and tissue samples were taken for histopathological examination. The following results were obtained: 1- Sildenafil significantly decreased the serum total lipid concentration of rats fed on fat- and cholesterol-enriched diet. However, |