الفهرس 
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Abstract
Wrinkles may be defined as creases or furrows in the skin surface, reflecting the underlying alteration in the delicate architecture of the dermal connective tissue. Collagen, elastin, and glycosaminoglycans (GAGs) are the skin components primarily responsible for contributing to the skin’s appearance. Less youthful skin appearance results from decreased levels of these constituents as we age.
The advent of dermal fillers, beginning with the FDA approval of bovine collagen for cosmetic use in 1982, has allowed less invasive corrective procedures with less recovery time. The basis for soft tissue augmentation using dermal fillers is to achieve a temporary, more youthful look in facial skin by replacing some of the building blocks of the dermal layer of skin lost through aging.
Cross-linked or stabilized hyaluronic acid is nowadays the most used resorbable filler. Since its first commercialization in 1996, many molecules have been marketed. These differ in the cross-linking or stabilization process, necessary to lengthen their degradation by hyaluronidase.
Restylane is a nonanimal stabilized hyaluronic acid (NASHA) of medium viscosity. It has been FDA approved in December 2003 for mid- to deep dermal correction. All NASHA-based hyaluorans contain 20 mg/mL of hyaluronic acid and differ only by particle size. Restylane Fine Line contains 200,000 gel particles per mL and is intended for fine lines and wrinkles to be injected in the superficial dermis (eg, crow’s feet and vertical lip wrinkles). Restylane contains 100,000 gel particles per mL and is indicated for injection in the middle dermis. Perlane contains 10,000 gel particles per mL and is intended for injection in the deep dermis or subcutis and Restylane SubQ contains 1000 gel particles per mL and is intended for injection in the subcutis.
Many benefits of using Restylane as a dermal filler include: low allergic potential, biocompatible and safe, giving a natural look and feel, lasting significantly longer than any of the collagens, moldable, very easy to be applied, readily prepared, and easy to inject.