الفهرس 
INRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Pesticides are occasionally used in large amounts causing environmental pollution and therefore, are a cause of concern. Synthetic pyrethroids are broad spectrum insecticides active to
varying degree on an extensive range of arthropod species and used widely against insect pests in agriculture, veterinary and domestic outlets. Lambda-cyhalothrin (LCT) is one of the type 11 newer synthetic pyrethroid insecticides with an effective, immediate and
persistent activity against a large variety of arthropods harmful both
to human and animal health and to vegetal production. from the previous studies there is no enough data on the
hepatotoxicity of LCT. Therefore, the present study aimed to investigate the hepatotoxicity of LcT either in vitro (for technical grade) or in vivo (for both technical grade and commercial 2.5%) beside an in vitro mechanistic study to elucidate the role of
microsomal enzymes in the LCT hepatotoxicity using inducers and
inhibitors models in freshly isolated male rat hepatocytes. I. In vitro hepatotoxicity study involves two experiments as following: The first experiment involved determination of cytotoxicity and oxidative stress induced by LCT in isolated rat hepatocytes at different concentrations (100, 200, 400 and 800 ng LCT / ml of
incubation medium) and time points of incubation (0, 30, 60 and 120 minutes). Cytotoxicity was determined by assessing of cell viability and hepatic enzymes (LDH, ALT ”and AST) leakages
percentage. Oxidative stress induced by LCT was measured by GSH content and TBARS accumulation. The results of this
experiment revealed the LCT exhibited concentration and time-