الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
As progenitor cells are activated in most chronic liver diseases that are known risk factor for the development of HCC, progenitor cells are potential target cells for carcinogenesis. The aim of this study was to detect the site of hepatic stem cells in patients with chronic liver disease and hepatocellular carcinoma and to correlate tissue expression levels of OV6, HGF, TGFB with grade of inflammation, stage of fibrosis and grades of HCC. This study was performed on 100 patients and 10 normal persons group I : 30 patients with chronic viral hepatitis. group II: 30 patients with cirrhosis. group III: Including 40 patients with hepatocellular carcinoma. group IV: control group. All patients were subjected to the following Complete history and clinical examination-CBC- ESR- Liver function tests- (PT) and concentration- Hepatitis seromarkers- Alpha fetoprotein: in HCC patients- Abdominal US- Abdominal CT: In HCC patients-Ultrasound guided liver biopsy -histopathological examination and immunohistochemical staining for OV6, HGF and TGFB1.