الفهرس 
CHRONIC HEPATITIS C AND LIVER CIRRHOSISOnly 14 pages are availabe for public view
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Abstract
The study was carried out on 40 hepatic patients selected from those admitted to tropical and internal medicine departments in Ahmed Maher Teaching Hospital. All patients were suffering from chronic liver disease due to HCV infection. They had no history, clinical or laboratory evidence of diabetes mellitus, hypertension and renal disease. The patients were not taking nephrotoxic drugs.
All patients divided into two groups: group I (30 patients with liver cirrhosis and hepatorenal syndrome), group II (10 patients with liver cirrhosis but without hepatorenal syndrome). Patients were selected according to International Ascites Club’s diagnostic criteria of hepatorenal syndrome.
The goal of our study was to assess the value of renal arterial resistive index measured by Duplex Doppler ultrasonography as a non invasive technique in comparison with 24 hours urinary sodium, serum creatinine and serum sodium in detection of renal dysfunction in patients with advanced chronic liver disease.
Multiple clinical and laboratory parameters were assessed at the time of Duplex Doppler ultrasonography. All laboratory and imaging procedures were carried out 48-72 hours after stopping diuretics.
The renal resistive index was measured by Duplex Doppler ultrasonography and calculated from interlobar artery in all studied patients and compared with other parameters that used in diagnosis of hepatorenal syndrome according to International Ascites Club’s diagnostic criteria of hepatorenal syndrome.
We found that:
• Resistive index was higher in group I of patients (0.805±0.044) than group II (0.688±0.024) with a statistiacally highly significant difference between the studied two groups (p<0.01).
• Resistive index was highly significant correlated with other parameters used in diagnosis of hepatorenal syndrome (serum creatinine, creatinine clearance, serum sodium and 24 hours urinary sodium).