الفهرس 
Helicobacter pyloriOnly 14 pages are availabe for public view
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Abstract
Summary
Stool antigen test is non invasive test that identifies active H.pylori infection by detecting presence of H.pylori in stools which can replace endoscopy in predicting infection and decide how to manage patients.
The present study was conducted on 55 elderly patients male or female, 60 years old and older, not in active gastrointestinal bleeding to evaluate the stool antigen test as a diagnostic tool for H.pylori infection in elderly population.
They underwent upper gastrointestinal endoscopy and were diagnosed to have gastric H.pylori infection by Haematoxylin and eosin stained films of gastric biopsies.
Regarding Stool Antigen Test results in our study in comparison to histopathology of H.Pylori in elderly patients, 45% sensitivity, 73.3 % specificity, 81.8% positive predictive value, negative predictive value 33.3% and accuracy 52.7%.
Regarding epidemiological data in our study, fourty patients were positive for H.pylori infection (72%) and fifteen were negative.
Also we found that age distribution among the studied patient ranged from 60 to 88 years old, with a mean of 66.6±5.9.
Regarding special habits no significant relationship was found between smoking, coffee, tea, spicy food and alcohol consumption and H.pylori infection.
Regarding the presenting symptoms among the studied patients, our study showed that the most prevalent upper gastrointestinal complaint was the epigastric pain as it was found in 23 patients (41.8 %) in all studied cases and 18 patients (45%) of H.pylori group.
Regarding medical history of studied patients, 33 patients (60%) were chronic liver disease.
Also, still in the present work, we found that no congnitive impairment in our studied patients and no association was between cognitive impairment and underlying H.pylori infection.
Concerning the endoscopic findings in our study, GERD was found in 3 out of 40 H.pylori positive patients involved in this study (7.5%). Antral gastritis was predominant in 12 cases (30%) followed by pan-gastritis in 6 cases (15%) and lastly corporeal gastritis in 1case (2.5%). Nodularity of gastric mucosa was found in 7 cases (17.5%). Atrophy, which was found in our study in 3 cases (7.5%). Regarding duodenitis, it was found in 10 cases (25%) and duodenal ulcer was found in 2 cases (5%) of our studied H.pylori positive patients.
As regards the histopathological examination of the gastric biopsy specimens of our patients, it was found that all the studied patients had chronic gastritis with mononuclear cell infiltration of the gastric mucosa. It was graded as mild, moderate and severe chronic gastritis according to the degree of the mononuclear cell infiltration. Most of H.pylori positive cases (57.5%) had moderate mononuclear cell infiltration.
In this chronic gastritis other four morphological changes were assessed; activity, atrophy, intestinal metaplasia and density of H.pylori. There was no statistically significant difference between the studied groups regarding these histopathological findings.