الفهرس 
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Abstract
.pylori is considered one of the most common bacterial infections in man, and considers the most common cause for active chronic gastritis. NO may play important role in the pathogenesis of H.pylori infection.
Nitric oxide (NO) is a small and short-lived signaling molecule having a vital role in many biological processes. High levels of NO have the opportunity to react with superoxide leading to peroxynitrite formation and cell toxicity.
Nitric oxide synthases (NOSs) are a family of eukaryotic enzymes that catalyze the production of nitric oxide (NO) from the terminal nitrogen atom of arginine in the presence of NADPH and dioxygen (O2).
In the present study our aim is to evaluate and study the relation between change in local production of INOs and degree of symptoms, pathological finding of H.pylori infection also the correlation between pathological finding and presenting symptoms.
To achieve this goal, sixty seven (67) children who referred for endoscopy due to upper gastrointestinal symptoms. Forty six (46) children of those children were diagnosed to have H.pylori infection by rapid urease test. Twenty one (21) children were diagnosed as H.pylori free person by the same test.
Histopathological assessment for gastric biopsies according to Sydney classification for gastritis, also iNOs level was assed, the degree of positivity assessed using a semi quantitative technique using (point counting technique).
Statistical analysis of data obtained from the present study showed the following results:
1- Gastritis was the most common finding in H.pylori infection.
2- Significant relation between H.pylori infection and the severity of grades of gastritis.
3- Significant relation was present between haematemsis and high grads of pathological changes in gastric biopsies.
4- H.pylori infection and Haematemsis showed relation with each other that relation was significant.
5- Duodenitis was the second most common finding after gastritis in H.pylori infected patients and it had significant relation with infection and haematemsis in infected group.
6- Esophagitis presented in 41.8% of patients but its relation with H.pylori infection or haematemsis was insignificant.
7- Nodular gastritis is the most common and most specific endoscopic finding in H.pylori infection.
8- No significant relation between H.pylori infection and level of INOs in gastric mucosa except for deep glandular iNOS.
9- There is significant relation between level of INOs and haematemsis as a symptom for H.pylori infection.