الفهرس 
Pharmacological HMG CoA inhibition (StatinsOnly 14 pages are availabe for public view
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Abstract
Sixty patients visiting Nasser institute outpatient clinics who were already on daily 10 mg atorvastatin that have already achieved serum LDL cholesterol levels ≤ 100 mg/dl were included in this prospective, randomized study. The patients were randomized to continue their daily treatment of 10 mg atorvastatin (standard treatment) or to shift to 10 mg atorvastatin every other day (every other day treatment) groups. Before the treatment and at a six weeks follow up visit, serum LDL, lipid profile and hs-CRP levels of all patients were measured after 14 hours fasting. Statistical analyses were performed Chi-square, unpaired t tests.
Results: In the reduced (every other day treatment) group, there was a significant rise in total cholesterol and LDL-cholesterol levels by the end of six weeks as compared to standard daily regimen (p<0.01), the difference between the changes in the other lipid parameters of the two groups was not found to be of statistical significance., the effects of both treatment arms on hs-CRP levels, did not differ significantly (p>0.05).
Conclusions: Alternate-day dosing of atorvastatin causes a significant total cholesterol and LDL –C rise but similar effects on Hs CRP if compared to of daily administration.