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Abstract This study was carried out to investigate the influence of glucocorticoids on some physiological functions of The study was carried out at the Department of Physiology, Faculty of Veterinary Medicine, Zagazig University. Sixty three mature male albino rats about 250±20 gram average body weights were allocated to three groups, twenty one rats for each. Group I consists of unstressed animals (control group); group II consists of the forced repeated swimming animals (stress group). The rats were exposed to forced swimming stress daily for duration of 15 minutes. Group III consists of dexamethasone treated animals injected daily through SIC route in a dose of 0.25 mg/Kg body weight. After 15 days of treatment, 7 rats from each group were sacrificed. Another 7 rats from each group were sacrificed after 30 days of treatment. The remaining 7 rats from each group were left for recovery and sacrificed after 15 days. Blood samples were collected at the time of sacrificing in tubes without anticoagulants for obtaining serum to be used for estimation of testosterone.jnsulin-like growth factor I and leptin hormone levels and other blood samples were collected in tubes with anticoagulant for determination of total and differential leucocytic count. Brain was quickly removed and stored at _20DC for determination of lipid peroxidation, reduced glutathione and superoxide dismutase activity. Testes were carefully excised and mixed with physiological saline then |