الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Systemic lupus erythematosus is a chronic autoimmune disease associated with the generation of pathological autoantibodies against multiple organs including the kidney.
LN remains the most common serious manifestation of SLE ,yet its pathogenesis is still unclear. Recently,many studies could prove that presence of autoantibodies play a central role in its pathogenesis.
The present study included 40 SLE patients (20 were lupus with nephritis and 20 were lupus without nephritis) and 20 healthy controls, aiming at studying the association of certain autoantibodies (anti-laminin, anti-C1Q and anti-fibronectin) with LN.
Studied groups were subjected to the following:
1- Registration of demographic data.
2- Recording historical data for patients including disease onset, disease duration and treatment strategy.
3- Thorough clinical examination.
4- Laboratory assessment including:
- ESR. - CRP
- Complete blood picture.
- Blood urea nitrogen (BUN) (mg/dl)
- Serum creatinine assessment (mg/dl)
- Complete routine Urine analysis.
- Urine for albumin ( Micral & total 24 hour protein)
- Spot urine test for creatinine concentration (mg/24h/1.75m2)
- Twenty-four-hour urine test for creatinine clearance and protein excretion.
- Anti-Laminin, anti-Fibronectin and anti- C1Q antibodies.
Regarding the results of current study:
There was significant difference between patients group(SLE with and without nephritis) and control group regarding anti-laminin antibodies.
It was found that there was a significant positive correlation between ESR 1st hour and anti-laminin and also a positive correlation was detected between the value of anti-laminin and 24 hrs urine creatinine clearance.
A positive correlation between anti-laminin and 24 hrs urine proteins was also approved. These result suggest that antibodies to this laminin molecule were shown to correlate with disease activity and active lupus nephritis .