الفهرس 
Inflammation, Atherosclerosis, and Coronary ArteryOnly 14 pages are availabe for public view
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Abstract
This study was done to find out the prognostic value of high sensitivity C-reactive protein among patients with anterior ST segment elevated MI (STEMI) and its correlation with short term prognosis.
Sixty patients with STEMI were included in this study. They were subjected to complete medical history, full clinical examination; laboratory investigations include (CPK, CPK -MB,hs- CRP and routine laboratory investigations) at admission and short term follow-up (six months after hospital discharge) for major adverse cardiac events.
The adverse cardiovascular events in hospital occurred in 11 patients (18.3%) Death occurred in 4 patients (6.7%), heart failure in 3 patients (5.0%), Ventricular tachycardia in two patients (3.3%), refractory angina in one patient (1.7%) and one patient underwent emergency CABG (1.7%).
Hs- CRP levels were significantly higher among patients with in-hospital complications than those without in-hospital complications as the mean level of hs-CRP was 22.97± 10.24 for patients with complications vs. 13.82 ± 10.01 for patients without complications (P <0.01)
Follow-up for cardiovascular events after 6 months was done to 55 patients. Three patients (5.5%) died, non-fatal MI occurred in 1 patients (1.8%), angina in 2 patients (3.6%) and heart failure occurred in 8 patients (14.5%),Urgent revascularization for one pateint 1.8% .
Hs- CRP levels were significantly higher among patients with cardiovascular complications during follow up than those without complications as the mean level of hs-CRP among patients with cardiovascular complications was 20.39±10.06 on the other hand the mean level of hs-CRP among patients without complications was 12.51±9.26 (P <0.01).
Multivariate analysis of the predictors of adverse cardiovascular events after 6 months showed that hs- CRP >10mg/dl mg was the most significant predictors of adverse cardiovascular events.
Univariate analysis for the role of hs- CRP > 10mg/dl, the hs- CRP was found to be associated with increase in the relative risk ratio of cardiovascular events by 5.2 folds (RR) , 95% CI ”between” 2.2 – 12.2, P < 0.002).
Analysis of the relation between serum level of hs-CRP and six months follow-up for cardiovascular events in patients treated with invasive versus conservative therapy, Chi square test for (conservative) is statistically significant for group of patients with hs- CRP >10mg/dl (X=5.880, P<0.05) they were statitistically significant and associated with adverse cardiac events after 6 months follow-up.