الفهرس 
CARDIAC BIOMARKERSOnly 14 pages are availabe for public view
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Abstract
ariable degrees of myocardial injury can occur during the course of percutaneous coronary intervention (PCI), as reflected by rises in cardiac enzymes such as creatine kinase (CK) and CK-MB. More recently, cardiac troponins T and I have emerged as highly sensitive and specific markers of myocardial cell injury.
Elevation of CK-MB after PCI is associated with increased risk of death, MI and repeat revascularization. Elevated cardiac Troponin after PCI is strongly associated with increased 90-day risks of major adverse cardiac events.
The current study was conducted on 149 patients presented to Dar Al Fouad hospital catheter laboratory for elective PCI in the period between March 2010 and October 2010. They were randomized into 2 groups, one undergoing remote IPC and the other a control group.
All patients were subjected to proper history taking, thorough clinical examination, were given 300 mg loading dose of clopidogrel at least 12 hours before the procedure and 10 000 IU IV heparin just before intervention. Coronary angiography followed by PCI was done with registration of angiographic and procedural variables. CK-MB and troponin T levels were measured prior to and 16 hours following the procedure.
The relations of demographic, clinical, procedural and post procedural variables were studied in each group individually and then the two groups were compared together.
Demographic variables had no significant relation to the elevation of CK-MB or Troponin T levels and were similar in both groups.
Clinical variables such as cardiovascular risk factors were also similar in both groups.
Angiographic variables (lesion type, lesion site, target vessel diseased) were all similar in both groups.
Procedural variables (direct stenting versus PTCA+ stent, GP IIb/IIIa inhibitors use, post-stenting inflations) were all similar in both groups.
The mean post-procedural cardiac troponin T level was significantly lower in the RIP group. Also the number of patients who developed post-procedural myocardial infarction was much lower in the RIP group, yet the value did not reach statistical significance.
Post procedural levels of CK-MB and CRP however showed no significant difference in both groups.